because這個連接詞表示的是因果關係，而in that則用於補充說明，特別是用來解釋它所修飾的句意。

例句：

In that CFC's react with ozone molecules and break them down, a large hole regularly appears in the ozone layer above Antarctica.

上面這個句子中，兩個子句之間是明顯的因果關係，應使用because 來連接，成爲：

Because CFC's react with ozone molecules and break them down, a large hole regularly appears in the ozone layer above Antarctica.

in that的用法，它是in the sense that的省略。省略掉the sense，是因爲它沒有內容，所代表的意思完全是後面的同位格 that子句中的敘述。請看這個例子：

The Montreal protocol was a landmark in global environmentalism in (the sense) that it brought together dozens of nations around the world for joint efforts to cut down the emission of CFC's into the atmosphere. (正確)

蒙特利爾公約是全球環保運動重要的里程碑，意思是說它結合了全世界幾十個國家，共同努力減低滲入大氣層的氟氯碳量。

由in that引導的子句，主要功能在於說明前面主要子句的意思，尤其是解釋清楚 a landmark in global environmentalism 這個稍嫌籠統的詞是什麼意思。這個功能和because表示因果關係的功能不盡相同，不可混爲一談。